Supplements for Slow COMT

February 17, 2024 5 mins to read

In a previous article I covered the basics of slow COMT, including symptoms, as well as diet and lifestyle tips to address it. In this article I talk specifically about slow COMT supplements and important nutrients.

What is COMT? and What does slow COMT mean?

The COMT (Catechol-O-methyltransferase) gene plays a crucial role in the metabolic breakdown of key neurotransmitters including: dopamine, epinephrine, and norepinephrine – vital for managing stress, regulating mood, and overseeing executive functions. A gene mutation known as “slow COMT” leads to a reduced functionality of the COMT enzyme, resulting decreased breakdown of these neurotransmitters. This slower breaking down of neurotransmitters, can influence various physiological and especially psychological function and performance. Below is a summary of potential implications associated with the slow COMT gene variant:

  • Anxiety and Stress Sensitivity: Those with the slow COMT variant often report increased anxiety levels and an elevated sensitivity to stress, attributed to the slower metabolism of adrenaline and noradrenaline.
  • Mood Swings: The crucial role of dopamine in mood regulation means that any imbalance can lead to notable mood swings.
  • Increased Pain Sensitivity: A greater sensitivity to pain could arise from the elevated levels of catecholamines, affecting pain perception.
  • Difficulty Sleeping: The involvement of catecholamines in regulating sleep patterns may cause individuals with slow COMT to struggle with sleep-related issues.
  • Hormonal Imbalance (Women): For women, the slow COMT variant can exacerbate the symptoms associated with hormonal fluctuations during menstrual cycles or menopause.
  • Reduced Stress Tolerance: Managing stress could become more challenging, with individuals experiencing greater physical and psychological impacts during stress.
  • Enhanced Productivity: Due to unusually high dopamine levels certain cognitive functions can be improved, though there can also be difficulties in specific learning or memory tasks.
    • Difficulty Concentrating: Elevated dopamine levels may also hinder focus.

Slow COMT Supplements

These are some of the most important slow COMT supplements because someone with a slow COMT enzyme, has difficulty metabolizing certain neurotransmitters like dopamine, therefore these certain supplements may help balance neurotransmitter levels and support overall cognitive and physical health. Here’s a list of slow COMT supplements, including vitamins and minerals, that might be beneficial for slow COMT:

Please Note: Slow COMT Supplements aren’t a magic bullet solution! A holistic approach to cleaning genes with diet and lifestyle is highly recommended, and supplements should only be used under the advisement of a professional. Book a video call (all you need is a smartphone) to set up a nutrition plan.


Can act as a natural calcium channel blocker, which may help to calm neuronal activity and reduce anxiety.

Vitamin B6 (Pyridoxine)

Essential for the synthesis of neurotransmitters, including dopamine. It can help in the conversion of dopamine to norepinephrine, a process that slow COMT individuals might struggle with.


Plays a role in neurotransmitter regulation and has been shown to have a calming effect on the nervous system.

Omega-3 Fatty Acids

Found in fish oil, they can help improve mood and cognitive function by supporting brain cell structure and neurotransmitter function.

SAM-e (S-adenosylmethionine)

As a methyl donor, SAM-e can support the methylation process, which is crucial for individuals with slow COMT as it helps in the breakdown of dopamine.

Vitamin C

Apart from its antioxidant properties, vitamin C can also contribute to dopamine synthesis and may help in managing stress levels.

N-Acetyl Cysteine (NAC)

Acts as an antioxidant and can also influence neurotransmitter levels, potentially benefiting those with slow COMT by supporting the body’s natural detoxification processes.

Rhodiola Rosea

An adaptogenic herb that may help increase the resistance to stress and normalize dopamine levels in the brain, which could be beneficial for those with slow COMT.

Green Tea Extract

Contains EGCG, which can influence enzyme activity and neurotransmitter balance. It’s thought to possibly have a modulating effect on COMT activity.

Methylated B-Vitamins

Two of the most important slow COMT supplements Include methylfolate (B9) and methylcobalamin (B12), these forms are the bioactive (in the form the body can immediately use, without converting) more readily utilized by individuals with methylation issues, including those with slow COMT variants.

Again…It’s important to consult with a healthcare provider before starting any new supplement regimen, especially if you have a specific genetic makeup that affects your body’s biochemical (methylation) pathways. A professional can provide personalized advice based on your health history and current situation to optimize your health.

Check out my shop which contains the supplement I recommend and use with my clients in my professional practice. One of my favorite brands is Truehope Empower Plus – Methylated Advanced – One of the most studied micronutrient formulas with 36 essential nutrients including methylfolate and methylcobalmin. The company and supplement has hundreds of rave reviews and backing it a team of naturopaths and nutrition experts, which provide free support with your purchase, and can help you manage your medications.


The information provided in this article is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of any health care agency or government entity in Canada or the United States.

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