Polyphenols for Weight loss

July 10, 2023 5 mins to read

Polyphenols are naturally occurring plant based compounds, that have gained popularity for their impact on human health. Two in particular: resveratrol and grape seed extract have sparked interest in the scientific community for their ability to powerfully boost cellular efficiency and aid in weight-loss.

Polyphenols as Mito-Boosters

Dr. Steven Gundry refers to polyphenols as Mito-Boosters, or Mitochondrial Boosters. The mitochondria are the powerhouses of your cells, responsible for generating all the energy your cells need to do literally everything that makes your body work. By boosting the mitochondria in your cells, polyphenols can increase the efficiency of your many cellular processes, which can support weight-loss in a variety of ways.

Polyphenol Properties & Weight-loss

Polyphenols are abundant in various foods including: fruits, vegetables, whole grains, tea & wine. They possess a broad range of health benefits, including anti-inflammatory, antioxidant, and anticarcinogenic properties[1].

New studies show polyphenols also play a crucial role in weight-loss by influencing lipid metabolism and promoting fat burning. They have the ability to reduce excessive body fat, enhance metabolic activity, decrease inflammation, and improve gut health, thereby facilitating weight loss[2].

Resveratrol: More Than Just an Anti-aging supplement

Found predominantly in grapes’ skin and red wine, resveratrol is a type of polyphenol that has long been heralded for its longevity and heart (cardiovascular) health promoting affects. However, recent research has highlighted its potential as a weight-loss aid.

Studies show resveratrol may help with weight loss by: enhancing energy expenditure, reducing fat cell proliferation, and improving insulin sensitivity. Through those mechanisms, resveratrol may help mitigate obesity-related metabolic disorders[3].

Additionally, resveratrol can stimulate the expression of genes associated with longevity and calorie restriction, potentially leading to increased lifespan and better weight management[4].

Grape Seed Extract: A Weight-loss Powerhouse

Like resveratrol, grape seed extract is another potent source of polyphenols with potential benefits for weight-loss. It’s particularly rich in a type of polyphenol known as proanthocyanidins.

Grape seed extract has been shown in studies, to inhibit the formation of new fat cells and promotes the breakdown of existing ones, leading to a reduction in body fat[5]. It also exhibits strong antioxidant properties, which may help reduce inflammation often linked with obesity[6].

More fascinating is grape seed extract’s supportive role in gut health. It has been found to modulate the gut microbiota diversity, promoting the growth of beneficial bacteria linked with weight management and overall health[7].

Where to Buy

Both Resveratrol and grape seed extract are readily available as a supplement at virtually any health food store, which you can easily take with a glass of water along side meals. I am Youngevity Distributor, so I have two particularly effective supplements I recommend from Dr. Wallachs Formulas:

Dr. Wallachs Youngevity supplements are in my professional opinion some of the best on the market. That’s why I became a distributor and I use them myself daily as a nutrition expert. I also advocate for getting the 91 Essential nutrients to help prevent disease – his specialized Healthy Body Weight-loss Pak includes all 91 nutrients as well as formulas specially designed to aid in weight-loss – it is well worth the investment, if you are trying to lose weight and stay healthy.


Given the potential benefits of polyphenols, including resveratrol and grape seed extract, for weight loss, incorporating foods rich in these particular compounds, into your diet seems like a no brainer. But it should be noted that these powerful supplements should be taken as part of a healthy diet (such as a ketogenic or custom diet), designed to help you lose weight. In addition combining diet and supplementation as part of a holistic (whole health) plan that involves physical activity, adequate hydration and mental health support – are all vital components in your weight-loss journey. You can hire me as your weight-loss professional by booking a Nutritional Consult (online to anywhere in the world via Zoom Video Call) and we can get you started on a custom holistic weight-loss plan that makes you feel healthier and happier, while ensuring success.


  1. Pandey, K. B., & Rizvi, S. I. (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity, 2(5), 270-278.
  2. Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo-Ortuño, M. I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. The Journal of Nutritional Biochemistry, 24(8), 1415-1422.
  3. Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., … & Schrauwen, P. (2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism, 14(5), 612-622.
  4. Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., … & Sinclair, D. A. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342.
  5. Terra, X., Montagut, G., Bustos, M., Llopiz, N., Ardèvol, A., Bladé, C., … & Pujadas, G. (2009). Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. The Journal of Nutritional Biochemistry, 20(3), 210-218.
  6. Charradi, K., Sebai, H., Elkahoui, S., & Ben Hassine, F. (2017). Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis. Cardiovascular Toxicology, 17(2), 160-169.
  7. Bialonska, D., Ramnani, P., Kasimsetty, S. G., Muntha, K. R., Gibson, G. R., & Ferreira, D. (2010). The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. International Journal of Food Microbiology, 140(2-3), 175-182.

Leave a comment

Your email address will not be published. Required fields are marked *