Lions Mane for Brain Health, Memory and Anti-Cancer

December 17, 2023 7 mins to read

As an Integrative nutrition student in college to become a holistic nutritionist…I have seen and experienced the loss of loved ones to Cancer, and have taken a particular interest in researching the topic. I authored the Alexa Anona Protocol for Cancer a comprehensive nutritional guide to cancer. Lions mane comes from Asian medicine and mainstream medicine is finally catching up with research that shows promising anti cancer properties. In this article I take a brief look into Lions mane cancer fighting potential.

They Don’t Call it Lion’s Mane for Nothing!

Lion’s Mane (Hericium erinaceus) isn’t just another mushroom it’s a nutritional powerhouse bursting with beneficial health effects. It’s more popualar for it’s memory and brain boosting effects, but it also strengthens immune function, lowers inflammation and even possesses anti-cancer properties – making it stand out in the medicinal mushrooms arena.

Lions Mane Anti Cancer Potential

There are many studies on Lions mane, some of which have shown that Lion’s Mane extracts can slow down or even halt tumor growth by inducing apoptosis (cancer cell death) and inhibiting metastasis (spread of cancer cells) – helping Lions mane to attack two main growth vectors for cancer! Not only that but it’s a powerful antioxidant and anti-inflammatory both of which support your bodies ability to fight cancer.

Lions Mane Cancer | Specific Cancers

Lions mane is mainly known for it’s ability to help with Leukemia and gastrointestinal cancers, but it’s anti-cancer properties work against a broad range of cancers, including:

  • Breast Cancer: Lions mane has been shown to inhibit the survival of breast cancer cells and induce apoptosis, offering hope for improved health outcomes in women battling this form of cancer.
  • Leukemia: In blood cancer, its compounds help inhibit growth and promote cancer cell death. A promising herb for fighting this challenging form of cancer.
  • Lung Cancer: The mushroom has antioxidant abilities, helping to effectively combat lung carcinoma cells.
  • Brain Cancer: Novel compounds from Lion’s Mane can potentially inhibit glioma, a common brain tumor. But more research is needed.
  • Gastrointestinal Cancers: Its anti-cancer potential is also evident against various gastrointestinal (digestive tract) cancers, including colon cancer.

Synergy with Conventional Treatments

Despite the fact that more traditional cancer treatments like chemotherapy’s over 90% failure rate, many people opt for this deadly treatment. Lions mane can help to potentially enhance the effectiveness of some treatments and may even help with some of the side effects of chemo. This positions Lions mane as a great adjunct cancer treatment (used along-side chemo). I can’t quite wrap my head around why some patients will opt out of including powerful dietary options like Lions mane, when they can be a powerful ally to more traditional chemo treatments.

One thing to note is that different chemotherapy drugs function differently, and some foods or supplements could affect them. I recommend you see a naturopathic doctor to ensure your diet and supplement plan are safe for you and book an appointment so I can make adjustments to your diet and supplements accordingly.

Lions Mane | Beyond Cancer Treatment

Lions Mane is a unique superfood that supports the health of those affected by cancer in multiple ways: From boosting the immune system to alleviating chemotherapy-induced side effects like nausea, fatigue, and cognitive impairment, it improves the quality of life for those undergoing cancer treatment.

Incorporating Lion’s Mane into Your Diet

You can enjoy Lion’s Mane in various forms – fresh in dishes, dried in teas, or as supplements. When choosing supplements, ensure they’re:

  1. High Quality with high % of bioactive compounds
  2. Are third party tested and checked for purity
  3. Are high quality and contain a range of bioactive compounds for maximum benefit.

Safety and Long-Term Use of Lions Mane

Generally well-tolerated, Lion’s Mane is considered safe for long-term use. However, some may experience gastrointestinal discomfort or allergic reactions, so always start with a small amount and if you experience any adverse affects stop and contact a professional. You can also book an online video call appointment with me to get started on Lions Mane as part of your nutrition plan. If you are on medications or other supplements, It’s also best you consult with your pharmacist to check for any interactions.

The Only Lions Mane Brand(s) I Trust

I have expensive tastes and I’m obsessed with quality…if I recommend a supplement I want to know it is the highest quality form available on the planet! I want to know with 100% confidence that those who trust me on my social media and blog, will reap the full medicinal benefits of the herbs and supplements I recommend. The only two mushroom extract brands I trust are:

  • Paul Staments Host Defense brand
  • Real Mushrooms – they are USDA organic and scientifically verified for maximum bioactive compounds.

Final Thoughts on Lions Mane | Conclusion

Lion’s Mane is a superfood and an anti-cancer powerhouse- fortifying the immune system in several ways including via it’s anti-inflammatory and anti-oxidant affects…but more research (pre-clinical and human trials) is needed. What makes Lion’s mane such a special option is it’s ability to be used along-side traditional cancer treatments to potentially enhance their effect and help with some of the side effects of these deadly traditional chemo (and radiation) treatments. Ultimately Lion’s mane can be a powerful addition to an anti-cancer diet, as advocated in my Alexa Anona Protocol for Cancer.


  1. Recent Developments in Mushrooms as Anti-Cancer Therapeutics: A Review
  2. Isolation and Identification of Aromatic Compounds in Lion’s Mane Mushroom and Their Anticancer Activities
  3. Transcriptome-Wide Analysis Reveals the Molecular Mechanism of Tumoricidal Effects of Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Agaricomycetes), on MCF-7 Breast Cancer Cells
  4. Mechanism of Hericium Erinaceus (Yamabushitake) Mushroom-Induced Apoptosis of U937 Human Monocytic Leukemia Cells
  5. Isolation and Identification of Aromatic Compounds in Lion’s Mane Mushroom and Their Anti-Cancer Activities
  6. Peptides Obtained from Edible Mushrooms: Hericium Erinaceus Offers the Ability to Scavenge Free Radicals and Induce Apoptosis in Lung Cancer Cells in Humans
  7. Hericium Erinaceus (Lion’s Mane) Mushroom Extracts Inhibit Metastasis of Cancer Cells to the Lung in CT-26 Colon Cancer-Transplanted Mice
  8. Erinacerins, Novel Glioma Inhibitors from Hericium Erinaceus, Induce Apoptosis of U87 Cells through Bax/Capase-2 Pathway
  9. Anti-Cancer Potential of Hericium Erinaceus Extracts Against Human Gastrointestinal Cancers
  10. Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation


The information provided in this article is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of any health care agency or government entity in Canada or the United States.

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