Methylfolate Side Effects

April 10, 2024 3 mins to read

Are you aware of methylfolate side effects? Getting too much folate (also known as folic acid or vitamin B9) from food at least is generally not a concern as it’s water-soluble and excess amounts are usually excreted through urine. However, excessive intake of folate/methylfolate supplements can lead to certain side effects.

L Methylfolate Side Effects List

Here are some potential symptoms of getting too much folate/methylfolate:

  1. Nausea and vomiting: Excessive folate intake may lead to gastrointestinal discomfort, including nausea and vomiting.
  2. Irritability and restlessness: Some individuals may experience symptoms of irritability, restlessness, or even difficulty concentrating.
  3. Insomnia or disturbed sleep: Excessive folate intake may interfere with sleep patterns, leading to insomnia or disturbed sleep.
  4. Digestive issues: In addition to nausea and vomiting, excessive folate intake may cause other digestive issues such as diarrhea or abdominal cramps.
  5. Skin reactions: Some individuals may develop skin reactions such as itching, rashes, or flushing as a result of too much folate.
  6. Masking of vitamin B12 deficiency: High folate levels can mask a vitamin B12 deficiency, which is particularly concerning as a B12 deficiency can lead to neurological problems if left untreated.
  7. Increased risk of certain cancers: There’s some evidence suggesting that excessive folate intake, particularly from supplements, may increase the risk of certain cancers, although more research is needed to fully understand this association.

It’s important to note that the recommended dietary allowance (RDA) for folate varies depending on factors such as age, gender, and pregnancy status.


I another article I reviewed overmethylation vs undermethylation symptoms. Most people do not get proper MTHFR testing, or they begin with a methylated supplement, without consulting a professional (book a virtual call). If you begin experiencing side effects including those of overmethylation. You should stop and consult a Genetic Counselor or Genomics Trained Naturopathic Dr. Here is a brief review of overmethylation symptoms.

  • Anxiety or agitation
  • Insomnia or difficulty sleeping
  • Racing thoughts or hyperactivity
  • Digestive issues (nausea, diarrhea)
  • Allergic reactions
  • Headaches or migraines
  • Mood swings or irritability
  • Muscle tension or tremors
  • Fatigue or lethargy
  • Cognitive difficulties (difficulty concentrating, memory problems)

The Best Methylfolate MultiVitamin

If you don’t want to guess at getting the right amount and wanted a tested, studied and safe methylfolate supplement, I can personally vouch for TrueHope Empower Plus Methylated Advanced – it’s one of the most studied micronutrient formulas on the market! And is designed as a safe daily multi-vitamin that contains methylfolate and methylcobalmin, to support MTHFR and proper methylation. I am extremely picky about only using and promoting premium quality supplements and highly recommend it!


The information provided in this article is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of any health care agency or government entity in Canada or the United States.

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