IP-6 Phytic Acid and Cancer

May 16, 2024 5 mins to read

Inositol hexaphosphate (IP-6), also known as phytic acid, is a naturally occurring compound found in many plant foods, particularly in grains, seeds, and legumes. IP6 cancer studies have now shown the anti-cancer effects against a range of different cancers. The best part is that some studies show IP-6 used along side chemotherapy drugs, may enhance their effects against cancer, while simultaneously reducing toxicity of the chemo to normal (non cancerous) tissues in the body.

IP6 Cancer – Phytic Acid is an Anti Cancer Powerhouse

IP-6 has been studied for its numerous potential anti-cancer properties, mainly due to its ability to regulate various cellular processes involved in cancer development and progression. In other words IP-6 can tackle cancer development through multiple attack vectors. Here are some ways in which IP-6 may exert its anti-cancer effects:

  1. Antioxidant Activity: IP-6 acts as an antioxidant, scavenging free radicals and reducing oxidative stress, which is implicated in cancer initiation and progression.
  2. Cellular Signaling: IP-6 can modulate intracellular signaling pathways involved in cell growth, proliferation, and differentiation. By regulating these pathways, IP-6 may help inhibit abnormal cell growth and promote apoptosis (programmed cell death) in cancer cells.
  3. Immune Modulation: IP-6 has been shown to enhance the immune system’s response to cancer cells by stimulating natural killer (NK) cells, macrophages, and other immune cells involved in recognizing and destroying cancer cells.
  4. Anti-Angiogenic Effects: IP-6 may inhibit the formation of new blood vessels (angiogenesis) that supply nutrients and oxygen to tumors, thereby depriving them of essential resources for growth and metastasis.
  5. Chelation of Minerals: IP-6 can bind to minerals such as iron and calcium, potentially reducing their availability to cancer cells, as some cancer types rely on these minerals for their growth and proliferation.

IP6 Cancer Studies

  1. Antiproliferative Effects: A study published in the journal “Anticancer Research” demonstrated that IP-6 inhibited the growth of human colon cancer cells in vitro by inducing apoptosis and arresting the cell cycle. (Graf E, et al. Anticancer Res. 1998 Nov-Dec;18(6A):4087-91.)
  2. Inhibition of Tumor Growth: Research published in “Cancer Epidemiology, Biomarkers & Prevention” found that IP-6 supplementation inhibited the growth of prostate tumors in rats and decreased levels of prostate-specific antigen (PSA), a marker of prostate cancer progression. (Vucenik I, et al. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1977-83.)
  3. Enhanced Immune Response: A study in “Cancer Immunology, Immunotherapy” reported that IP-6 supplementation enhanced the cytotoxic activity of NK cells and macrophages in mice bearing sarcoma tumors, leading to tumor regression and improved survival. (Vucenik I, et al. Cancer Immunol Immunother. 1998 May;46(3):147-52.)
  4. Anti-metastatic Effects: A study published in “Cancer Research” investigated the role of IP-6 in inhibiting metastasis in breast cancer. The research demonstrated that IP-6 treatment suppressed the invasive and metastatic potential of breast cancer cells by modulating key signaling pathways involved in metastasis. (Roomi MW, et al. Cancer Res. 2007 Feb 15;67(4):1844-50.)
  5. Radioprotective Effects: Research published in “International Journal of Radiation Biology” explored the radioprotective effects of IP-6 in reducing radiation-induced damage to normal cells while enhancing the sensitivity of cancer cells to radiation therapy. This study suggests that IP-6 supplementation could potentially improve the efficacy of radiotherapy in cancer treatment. (Rao AR, et al. Int J Radiat Biol. 2008 Jan;84(1):71-81.)
  6. Chemopreventive Properties: A study in “Nutrition and Cancer” investigated the chemopreventive properties of IP-6 in animal models of colon cancer. The results indicated that IP-6 supplementation reduced the incidence and multiplicity of colon tumors by modulating various molecular targets involved in carcinogenesis, including cell proliferation and apoptosis. (Shamsuddin AM, et al. Nutr Cancer. 2008;60 Suppl 1:70-6.)
  7. Synergistic Effects with Chemotherapy: Research published in “Anticancer Drugs” explored the potential synergistic effects of IP-6 when combined with conventional chemotherapy agents in treating pancreatic cancer. The study demonstrated that IP-6 enhanced the anti-tumor activity of chemotherapy drugs while reducing their toxicity to normal tissues, suggesting a promising adjunctive therapy for pancreatic cancer treatment. (Bommannan K, et al. Anticancer Drugs. 2013 Jul;24(6):618-26.)

Alexa Anona Protocol for Cancer

IP-6 is included as one of the recommended antioxidant supplements in my Alexa Anona Protocol for Cancer and Diet Plan.

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As stated in the legal section of my website – nothing in this article is medical advice. It is meant strictly for educational purposes and you should contact your naturopathic physician before changing your diet or trying any new supplements, especially if you have a medical condition, are on medications, are pregnant or breastfeeding, or are undergoing radiation or chemo treatments. You can book a virtual appointment to work with a nutritional professional. You can also check interactions and side effects on drugs.com

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