GeneSight Vs Genetic Methylation Test

January 5, 2024 4 mins to read

In this article I want to address a question I had on one of my my TikTok videos about the GeneSight test and if it was different than a methylation test. The short answer is yes a Genesight test is a completely different test which analyzes 14 genes, completely unrelated from the MaGen Methylation Test and the 180 or so genetic variants related to methylation that it looks at. But let’s look at what each test offers, and how they are different. Hope you enjoy the read.

Understanding GeneSight: A Beacon for Psychiatric Treatment

GeneSight is a remarkable tool primarily used in psychiatric care used mainly to determine how your unique genetic makeup can influence your reaction to psychiatric medications – focusing on genes related to drug metabolism and neurotransmitter production.

GeneSight test looks at roughly 15 genes, including:

  • Cytochrome P450 enzymes: These are the superstars in drug metabolism, including CYP2D6, CYP2C19, CYP2C9, CYP3A4, CYP1A2, and CYP2B6.
  • Other important genes: Think of CES1A1, UGT1A4, and UGT2B15.
  • Neurotransmitter-related genes: SLC6A4, ADRA2A, and HTR2A, along with the notable COMT.
  • Hypersensitivity-related genes: HLA-A3101 and HLA-B1502, crucial for understanding drug reactions.

Basically Genesight is really only useful if you are taking psychiatric medications for a mental health condition and want to be proactive in checking how you might react according to your genetic makeup; a more personalized approach to your treatment plan. A Genesight test is usually administered by psychiatrists and psychologists.

The Comprehensive Methylation Panel: A Deep Dive into Your Health

The methylation panel is like a detailed map of your body’s methylation processes, which are vital for DNA repair, making neurotransmitters, detoxifying, and boosting immune function. This test covers a wide array of genes, including AHCY-01, APOE, BCMO1, CBS, and many others involved in methylation and detoxification pathways. Notably, it also tests COMT, a gene overlapping with the GeneSight test and crucial in methylation and neurotransmitter metabolism.

The Overlap and Why It Matters

COMT is the one gene tested in both a methylation test and genesight test. This gene is a key player in both methylation processes and neurotransmitter metabolism. But aside from that single gene, these are very different tests.

The Big Picture: How Genesight Test Differs

So largely a Genesight test and methylation panel are very different tests, for very different purposes:

  • GeneSight: A specialized tool focusing on how your body might react to psychiatric drugs. For your practitioner to offer personalized medication advice.
  • Methylation Panel: A Swiss Army knife – offers a broad look at your health, particularly how your body handles methylation, which affects everything from mental health to how your immune system works.
    • The MaxGen Methylation Panel tests roughly 180 gene variants, and includes a detailed report explaining lifestyle, diet and supplement recommendations tailored to your genetic makeup.

Final Thoughts | Conclusion

When dealing with health issues information is key to uncovering root causes and what you can do to get on track to improving your health. So if it’s a more personalized psychiatric treatment plan, then discuss a Genesight test with your phychiatrist. Or If you’ve tried everything and want to get to the root causes of your: chronic health, mental health or autoimmune conditions…then consider a Methylation Panel at-home test kit that provides a detailed report so you can start changing your diet to get on the path to recovery. Just remember that these tests provide a few pieces to your health puzzle, but more tests and how you apply the information is key. Book a video call with a nutrition professional because they can help you get to the root cause(s) of your health issues.

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The information provided in this article is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of any health care agency or government entity in Canada or the United States.

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