Clodronate: A Beacon of Hope in Cancer’s Battle Against Bone Metastasis

December 22, 2023 6 mins to read

Clodronate, typically used to manage bone conditions like osteoporosis and managing elevated blood calcium levels often associated with cancer -It can be a very effective medicine for bone cancer and metastasis. It is however a synthetic pharmaceutical drug, and has a rage of potential side effects. In this article I’ll go over what it is, it’s potential for bone cancer ad metastasis and include studies backing up it’s potential benefits.

A Bit About Me

Normally I’m anti-bigpharma and cover natural remedies and medicines only. However sometimes there is a medicine or repurposed drug that deserves merit, especially in cases of acute illness. When it comes to Cancer, anything that can kickstart or boost the bodies ability to combat it is worth looking into, depending of course on the potential side effects. And with that in mind let’s Dig into Clodronate and it’s cancer fighting ability.

I have also done significant research into nutrition for cancer including authoring the Alexa Anona Protocol for Cancer, and articles on natural cancer remedies like Hoxseys Herbal Remedy, Essiac Tea and the Budwig Protocol (to name a few). If you want to improve your chances of recovery, book a video call appointment to have me as your nutrition expert, set you up with the best anti-cancer diet and nutrition plan.

What is Clodronate?

Clodronate, a bisphosphonate drug, is a key player in the management of various bone conditions. Its primary role lies in treating osteoporosis, a condition characterized by weakened bones, and managing elevated blood calcium levels often associated with cancer. Clodronate’s unique mechanism of action involves inhibiting the action of osteoclasts, the cells that break down bone tissue, thereby slowing bone loss and aiding in the preservation or improvement of bone density. This medication stands as a critical tool in the realm of bone health, offering relief and support to those grappling with complex bone diseases.

Soothing the Pain of Bone Metastases

Cancer that has spread to the bones is one of the most painful forms of cancer. In a robust, double-blind, placebo-controlled study, clodronate was shown to significantly reduce bone pain associated with conditions like bone metastases. This is beneficial because it can help individuals to have less of a need for painkillers and better adhere to a treatment plan.

A Ray of Hope for Reducing Bone Relapse

In the long marathon of cancer treatment, keeping the disease from coming back is a big win. In a 5-year study, Clodronate was shown to significantly reduce risk of bone metastases – which persisted over 2 years of medication use – helping to prevent relapse and improve survival rater over a longer-term.

Breast Cancer and Bones – A Delicate Dance

When breast cancer metastasizes (spreads) to bones, besides the cancer itself being an issue, it can lead to complications like fractures, spinal issues, and significantly more pain. Clodronate therapy has been one of the go-to treatments for better managing cancer that has affected the bones.

Prostate Cancer’s Bone Dilemma Solved?

Prostate cancer can be a real boner argh…I mean bummer (I’m sorry I had to). Besides that inappropriate attempt at comic relief…a study showed that in men facing prostate cancer clodronate provided significant improvements in bone pain – showing that for prostate cancer that has spread to bones, clodronate therapy is another effective option as part of a treatment plan.

Keeping Breast Cancer at Bay

So we covered bone metastasis and prostate cancer, how about breast cancer? Clodronate was shown to reduce metastases connected with breast cancer. Tis is valuable knowing that it can help better control breast cancer and it’s spread.

Final Thoughts | Conclusion

Clodronate seems like a game-changer in managing bone pain and reducing the risk of bone metastases for certain cancers. But it’s not a magic bullet for curing cancer, it’s just another option in a comprehensive holistic treatment plan that can include medicines, natural remedies, anti-cancer foods/herbs, spiritual/energy practices and lifestyle changes. Allot of people think it either has to be natural cancer treatment or traditional chemo/radiation cancer treatment…but nothing is further from the truth. You can of course benefit from the best of both worlds – natural remedies and pharmaceutical medicines to varying degrees – to support your body’s fight against cancer and get you back on track to better health. As with any treatment, these decisions are best made with your healthcare team. If you want help on the nutrition side to get set up with an anti-cancer diet – book an online video call appointment and let’s get you started.


  • “Effect of Oral Clodronate on Metastatic Bone Pain”: A comprehensive study on the effects of Clodronate in reducing bone pain for metastatic bone disease patients. Read more.
  • “Reduction in Bone Relapse and Improved Survival with Clodronate”: Insights into how Clodronate reduces the risk of bone metastases over a significant period. Explore the study.
  • “Treatment and Prevention of Bone Metastases from Breast Cancer”: Understanding the role of Clodronate in managing complications from breast cancer bone metastases. Find out more.
  • “Clodronate Therapy in Prostatic Carcinoma”: A study highlighting the effectiveness of Clodronate in alleviating bone pain in prostatic carcinoma. Learn more.
  • “Reduction in New Metastases in Breast Cancer with Adjuvant Clodronate”: Research showing Clodronate’s role in managing breast cancer-related bone metastasis. Discover details.


The information provided in this article is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of any health care agency or government entity in Canada or the United States.

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